Modell Foundation

10 Warning Signs of Primary Immunodeficiency (Children)

1. Four or more new ear infections within 1 year.
2. Two or more serious sinus infections within 1 year.
3. Two or more months on antibiotics with little effect.
4. Two or more pneumonias within 1 year.
5. Failure of an infant to gain weight or grow normally.
6. Recurrent, deep skin or organ abscesses.
7. Persistent thrush in mouth or fungal infection on skin.
8. Need for intravenous antibiotics to clear infections.
9. Two or more deep-seated infections including septicemia.
10. A family history of primary immunodeficiency.

10 Warning Signs of Primary Immunodeficiency (Adult)

1. Two or more new ear infections within 1 year.
2. Two or more new sinus infections within 1 year, in the absence of allergy.
3. One pneumonia per year for more than 1 year.
4. Chronic diarrhea with weight loss.
5. Recurrent viral infections (colds, herpes, warts, condyloma).
6. Recurrent need for intravenous antibiotics to clear infections.
7. Recurrent, deep abscesses of the skin or internal organs.
8. Persistent thrush or fungal infection on skin or elsewhere.
9. Infection with normally harmless tuberculosis-like bacteria.
10. A family history of primary immunodeficiency.

Primary Immunodeficiency in Clinical Practice

• 50% - antibody
• 20% - combined
• 18% - phagocytic
• 10% - cellular
• 2% - complement

References